July 2026
Weight Regain and GLP-1 Maintenance Dosing
People often wonder if they must continue taking GLP-1 medication to maintain weight loss results. A new study of around 400 adults evaluated the efficacy of three tirzepatide (Mounjaro/Zepbound) dosage options after an initial 60-week weight-loss period. Group one continued at the max dose. Group two transitioned to a lower dose. The final group transitioned to a placebo.
At the end of the 52 weeks of max/lower/or no dose, the group that stuck to the max dose had overall 21.9% total weight loss, the lower dose group lost 16.6%, and the placebo group lost 9.9%. Participants were allowed a rescue dose of tirzepatide if their weight regain exceeded 50% of what was lost in the original 60 weeks. Only 8% of the max dose group required rescue therapy, compared with 25% on dose reduction and 67% on placebo. The results demonstrate that it’s often necessary to continue tirzepatide in order to maintain bodyweight reduction. However, dose reduction does provide a valuable alternative to complete discontinuation.
Dr. Neuman says: Despite regaining some weight, those in the placebo group still ended the 2-year trial with a 10% weight reduction from the start. This data will empower people with information to help them decide what to do with the dose after initial weight loss with GLP-1 medications.
Physical Activity Beneficial in Pregnancy
Even light physical activity can improve pregnancy outcomes. In a 2025 US-based cohort study, 470 pregnant individuals were equipped with motion-sensing devices to record their daily movement and steps. The study found that spending too much time sitting more than doubled the risk of complications (e.g., preeclampsia, gestational diabetes, preterm birth, and underweight infants) compared to folks who got in light movement! Moderate-to-high movement daily reduced the risk even further.
Dr. Neuman says: We used to tell many pregnant people to take it easy/stay in bed at the slightest signs of distress. Now that the tune is different; we are encouraging whatever activity folks can get.
Nutritional Therapy Beneficial for Depression
A new study wanted to see whether the keto diet had better results for helping with depression than a general healthy nutrition plan. 132 UK-based adults with treatment-resistant depression were divided into two groups: one received a 6-week ketogenic diet plan, while the other received a well-matched control diet. At the end of the study, depression severity decreased markedly in both groups.
Dr. Neuman says: This study suggests that there are multiple nutritional strategies that can help with depression. Keto was no better than a general healthy eating plan, and many folks have logistical issues with the ketogenic diet, and it may have a higher risk of complications (increased cholesterol, constipation), so I will continue to recommend general sustainable and kind changes we can make to help the nutrition be more brain-friendly (increased antioxidants [berries, nuts, greens], switch to complex carbs [whole grain, brown rice], and reduction of simple sugars).
